Bone Oedema and Erosions

MRI shows more than twice the sensitivity for bone erosion as conventional radiography. MRI can demonstrate inflammation and damage of inter-osseous ligaments in the hands, knees, and other joints.

• Dynamika allows discriminating between active and inactive foci of enthesitis as captured by MRI.
• Dynamika increases sensitivity for bone erosion, which would be particularly useful in assessment of patients with early arthritis where damage is minimal, assessment of the treatment strategy, and designing proof-of-concept studies
• Dynamika can allow visualising and quantifying changes attributable to pulsion of joint fluid through breaks in the articular surface, localized inflammation, or changes associated with trauma (microfracture or osteonecrosis)

Figure: MRI delivers more information faster and potentially can give patients ands doctors a window of opportunity for more effective treatment. Ultimately this might mean for the patient a difference between a relatively normal lifestyle and a disability. Left: Radiograph taken from a patient and showing erosion. Right: MRI of the same patient showing the same erosion, but taken 20 months prior to the Xray. Published by Dr. M. Boesen in 2008. Bone erosion can change very rapidly and correlates with pain and scintigraphic uptake of radiolabeled bone tracers, it may represent a very useful predictive imaging marker for patient selection and longitudinal assessment of treatment effect.