Rheumatoid Arthritis
‘Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is known to be the magnetic resonance imaging (MRI) method that most accurately visualizes the degree of histological synovial inflammation. However, typical current methods used for evaluation of the images are time consuming and observer dependent. The recent development of semi-automatic image processing software such as Dynamika help making DCE-MRI a useful clinical tool in the management of Rheumatoid Arthritis and other inflammatory joint diseases.’, Scandinavian Journal of Rhematology, M. Axelsen, Mikkel Ostergaard et al, 2011.
At Image Analysis, we work with world experts in rheumatology to ensure that Dynamika is the solution for your study or trail in Rheumatoid Arthritis.
Using MRI and Dynamika will enable you to
- Better understand of soft tissue inflammation process and as well as bone distraction. This provides much more reliable information then radiographs, where changes are seen two years after they were spotted in MR images
- Quantify true morphological changes, allowing to avoid distortion caused by projectional radiography
- Increase sensitivity for detecting early bone erosions and inflammatory activity
- Allow assessment of compositional (collagen, synovitis, water) and physiological (vascular perfusion) features in addition to morphology
- To make whole join assessment
- To diagnose earlier and achieve better treatment response
- To objectively measure effect of drug on patient condition and to see changes within days
- To easier differentiate healthy controls from active patients
These advantages can be leveraged in clinical trials of rheumatoid arthritis to increase discriminative power and to reduce uncertainties, which would allow reducing the cost of a trial and accelerating market entry.
Figure: Patients with RA on 0.2 scanner and 3T scanner, software screen shot